Rhesus IFNA14 / Interferon alpha-14 Protein (His Tag)

IFNA14

Catalog Number	P90107-C08Y
Organism Species	Rhesus
Host	Yeast
Synonyms	IFNA14
Molecular Weight	The recombinant rhesus IFNA14 comprises 176 amino acids and has a calculated molecular mass of 21 KDa.
predicted N	Cys 24
SDS-PAGE
Purity	> 90 % as determined by SDS-PAGE
Protein Construction	A DNA sequence encoding the rhesus IFNA14 (XP_001107576.1) (Cys24-Asp189) was expressed with a polyhistidine tag at the C-terminus.
Bio-activity	Measured in antiviral assay using WISH cells infected with vesicular stomatitis virus. The ED₅₀ for this effect is 40-200pg/mL.
Research Area	Immunology \|Inflammation / Inflammatory Mediator \|Inflammatory Cytokines & Chemoki and Receptors \|IL-10/Interferon Family
Formulation	Lyophilized from sterile PBS, 50 % Glycerol. 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background
Reference	Lau JY, et al. (1993) Discrepancy between biochemical and virological responses to interferon-alpha in chronic hepatitis C. Lancet. 342(8881): 1208-9. Kessler DS, et al. (1990) Interferon-alpha regulates nuclear translocation and DNA-binding affinity of ISGF3, a multimeric transcriptional activator. Genes Dev. 4(10): 1753-65. Gutterman JU. Cytokine therapeutics: lessons from interferon alpha. Proc Natl Acad Sci U S A. 91(4): 1198-205.