Mouse Serpinb6b Protein (His Tag)

NK13,ovalbumin,Spi12

Catalog Number	P50371-M08B
Organism Species	Mouse
Host	Baculovirus-Insect Cells
Synonyms	NK13,ovalbumin,Spi12
Molecular Weight	The recombinant mouse SERPINB6B consists of 387 amino acids and has a calculated molecular mass of 44 kDa. It migrates as an approximately 43 kDa band in SDS-PAGE under reducing conditions.
predicted N	Met 1
SDS-PAGE
Purity	> 92 % as determined by SDS-PAGE
Protein Construction	A DNA sequence encoding the mouse SERPINB6B (NP_035584.1) (Met 1-Pro 377) was expressed，with a polyhistidine tag at the C-terminus.
Bio-activity
Research Area	Immunology \|Inflammation / Inflammatory Mediator \|Plasma Cascade Systems in Inflammation \|Fibrinolysis System
Formulation	Lyophilized from sterile 50mM Tris, 100mM NaCl, pH 7.0, 10% gly 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background
Reference	Morgenstern KA, et al. (1994) Complementary DNA cloning and kinetic characterization of a novel intracellular serine proteinase inhibitor: mechanism of action with trypsin and factor Xa as model proteinases. Biochemistry. 33(11): 3432-41. Strik MC, et al. (2004) Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers. Blood.103(7): 2710-7. Scott FL, et al. (2007) SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes. J Biochem. 142(4): 435-42.