Mouse PILRB1 Protein (Fc Tag)

Fdact,FDFACT,Pilrb

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Catalog Number	P50219-M02H
Organism Species	Mouse
Host	Human Cells
Synonyms	Fdact,FDFACT,Pilrb
Molecular Weight	The secreted recombinant mouse PILRB1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 406 amino acids and has a calculated molecular mass of 45.8 kDa. As a result of glycosylation, the apparent molecular mass of rmIL1RAPL1/Fc monomer is approximately 55-60 kDa in SDS-PAGE under reducing conditions.
predicted N	Gly 29
SDS-PAGE
Purity	> 85 % as determined by SDS-PAGE
Protein Construction	A DNA sequence encoding the mouse PILRB1 (Q2YFS2) extracellular domain (Met 1-Gly 193) was fused with the Fc region of human IgG1 at the C-terminus.
Bio-activity
Research Area	Signaling |Signal Transduction |Protein Phosphorylation |Tyrosine Kinase |Receptor Tyrosine Kinases
Formulation	Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background
Reference	Wilson MD, et al. (2006) Comparative analysis of the paired immunoglobulin-like receptor (PILR) locus in six mammalian genomes: duplication, conversion, and the birth of new genes. Physiol Genomics. 27 (3): 201-18. Orr MT, et al. (2010) Natural killer cell education and tolerance. Cell. 142(6): 847-56. Mousseau DD, et al. (2000) PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta. J Biol Chem. 275 (6): 4467-74.