Mouse PGRL / IGSF8 Protein (Fc Tag)

AA033172,AU041109,ESTM34,EWI-2,KCT-4,PGRL,R75384

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Catalog Number	P51042-M02H
Organism Species	Mouse
Host	Human Cells
Synonyms	AA033172,AU041109,ESTM34,EWI-2,KCT-4,PGRL,R75384
Molecular Weight	The secreted recombinant mouse IGSF8/Fc is a disulfide-linked homodimer. The reduced monomer comprises 793 amino acids and has a calculated molecular mass of 85.8 kDa. The apparent molecular mass of the monomer is approximately 80 kDa in SDS-PAGE under reducing conditions.
predicted N	Arg 26
SDS-PAGE
Purity	> 90 % as determined by SDS-PAGE
Protein Construction	A DNA sequence encoding the mouse IGSF8 (NP_536344.1) extracellulkar domain (Met 1-Thr 577) was fused with the Fc region of human IgG1 at the C-terminus.
Bio-activity
Research Area	Cancer |Cancer immunology |Tumor-associated antigen
Formulation	Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background
Reference	Glazar AI, et al. (2009) Immunoglobulin superfamily member IgSF8 (EWI-2) and CD9 in fertilisation: evidence of distinct functions for CD9 and a CD9-associated protein in mammalian sperm-egg interaction. Reprod Fertil Dev. 21(2): 293-303. Murdoch JN, et al. (2003) Genomic organization and embryonic expression of Igsf8, an immunoglobulin superfamily member implicated in development of the nervous system and organ epithelia. Mol Cell Neurosci. 22(1): 62-74. Zhang XA, et al. (2003) EWI2/PGRL associates with the metastasis suppressor KAI1/CD82 and inhibits the migration of prostate cancer cells. Cancer Res. 63 (10): 2665-74.