Mouse Calnexin / CANX Protein (His Tag)
1110069N15Rik,AI988026,Cnx,D11Ertd153e
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| Catalog Number | P53126-M08H |
|---|---|
| Organism Species | Mouse |
| Host | Human Cells |
| Synonyms | 1110069N15Rik,AI988026,Cnx,D11Ertd153e |
| Molecular Weight | The recombinant mouse Canx consists of 473 amino acids and predicts a molecular mass of 53.9 kDa. |
| predicted N | His 21 |
| SDS-PAGE |  |
| Purity | > 90 % as determined by SDS-PAGE. |
| Protein Construction | A DNA sequence encoding the mouse Canx (NP_031623.1) (Met1-Pro482) was expressed with a polyhistidine tag at the C-terminus. |
| Bio-activity | |
| Research Area | Signaling |Signal Transduction |Signaling Pathway |Calcium Signaling |Calcium Binding Protein |Calreticulin Family | |
| Formulation | Lyophilized from sterile PBS, pH 7.4. 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | Calnexin is a calcium-binding protein that belongs to the calreticulin family. It interacts with newly synthesized glycoproteins in the endoplasmic reticulum. Calnexin seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse. |
| Reference |