Human SEZ6L2 / PSK-1 Protein (His Tag)

PSK-1

Catalog Number	P13969-H08H
Organism Species	Human
Host	Human Cells
Synonyms	PSK-1
Molecular Weight	The recombinant human SEZ6L2 consists of 720 amino acids and predicts a molecular mass of 77.3 KDa. It migrates as an approximately 104-117 KDa band in SDS-PAGE under reducing conditions.
predicted N	Leu 28
SDS-PAGE
Purity	> 95 % as determined by SDS-PAGE
Protein Construction	A DNA sequence encoding the human SEZ6L2 (AAH00567.1) (Met1-Ser736) was expressed with a polyhistidine tag at the C-terminus.
Bio-activity
Research Area	Neuroscience \|Neurotransmission \|Intracellular Signaling \|Regulation
Formulation	Lyophilized from sterile PBS, pH 7.4. 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background	SEZ6L2, also known as PSK-1, belongs to the SEZ6 family. It contains 3 CUB domains and 5 Sushi (CCP/SCR) domains. SEZ6L2 may contribute to specialized endoplasmic reticulum functions in neurons.SEZ6L2 presents on the surface of lung-cancer cells. SEZ6L2 should be a useful prognostic marker of lung cancers. Increased expression of this gene has been found in lung cancers, and the protein is therefore considered to be a novel prognostic marker for lung cancer.
Reference	Bedoyan JK. et al., 2010, Am J Med Genet A. 152A (6): 1567-74. Konyukh M. et al., 2011, PLoS One. 6 (3): e17289. Wang J. et al., 2011, Mol Syst Biol. 7: 536.