Human S100A2 Protein (Fc Tag)

CAN19,S100L

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Catalog Number	P10180-H01H
Organism Species	Human
Host	Human Cells
Synonyms	CAN19,S100L
Molecular Weight	The recombinant human Fc/S100A2 is a disulfide-linked homodimer. The reduced monomer consists of 334 amino acids and has a predicted molecular mass of 37.6 kDa. As a result of glycosylation, the apparent molecular mass of rh Fc/S100A2 monomer is approximately 40 kDa in SDS-PAGE under reducing conditions.
predicted N	Glu 20
SDS-PAGE
Purity	> 95 % as determined by SDS-PAGE
Protein Construction	A DNA sequence encoding the human S100A2 (NP_005969.1) (Met 2-Pro98) was expressed with the fused Fc region of human IgG1 at the N-terminus.
Bio-activity
Research Area	Cell Biology |Cell Cycle |Cell Differentiation
Formulation	Lyophilized from sterile 100mM Glycine, 10mM NaCl, 50mM Tris, pH 7.5 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background	The calcium-binding Protein S100A2 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 family genes are located as a cluster on chromosome 1q21, and S100 proteins consisting of at least 20 members are involved in the regulation of a number of cellular processes such as cell-cycle progression and cell differentiation. S100A2 was first detected in lung and kidney, and is mainly expressed in a subset of tissues and cells such as breast epithelia and liver. The S100A2 protein is a homodimer that undergoes a conformational change upon binding of calcium, and the active form functions in regulating cell proliferation and differentiation, gene transcription, and p53-dependent growth arrest and apoptosis. Accordingly, this protein is regarded as a putative tumor suppressor, and thus chromosomal rearrangements and reduced expression of S100A2 gene have been implicated in certain carcinomas.
Reference	Gimona, M. et al., 1997, J. Cell. Sci. 110: 611-621. Mueller, A. et al., 2005, J. Biol. Chem. 280: 29186-29193. Lapi, E. et al., 2006, Oncogene. 25: 3628-3637. Feng, G. et al., 2001, Cancer. Res. 61: 7999-8004. Gupta, S. et al., 2003, J. Clin. Oncol. 21: 106-112.