Human S100A12 / CAGC / Calgranulin-C Protein

CAAF1,CAGC,CGRP,ENRAGE,MRP-6,MRP6,p6,S100A12

Catalog Number	P11143-HNAE
Organism Species	Human
Host	E. coli
Synonyms	CAAF1,CAGC,CGRP,ENRAGE,MRP-6,MRP6,p6,S100A12
Molecular Weight	The recombinant human S100A12 consisting of 92 amino acids and has a calculated molecular mass of 10.6 kDa. It migrates as an 10 kDa band in SDS-PAGE under reducing conditions as predicted.
predicted N	Met 1
SDS-PAGE
Purity	> 98 % as determined by SDS-PAGE
Protein Construction	A DNA sequence encoding the native human S100A12 (NP_005612.1) (Met 1-Glu 92) was expressed.
Bio-activity	Measured by its binding ability in a functional ELISA . Immobilized recombinant human S100A12 at 2 μg/ml (100 μl/well) can bind human AGER with a linear range of 0.032-20 μg/ml .
Research Area	Immunology \|Signal Transduction \|Signaling Pathway \|Calcium Signaling \|Calcium Binding Proteins
Formulation	Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background
Reference	Moroz, OV. et al., 2001, Acta Crystallogr D Biol Crystallogr. 57: 20-9. Foell, D. et al., 2003, Lancet 361 (9365):1270-2. Vogl, T. et al., 2004, Blood. 104: 4260-8. Viemann, D. et al., 2005, Blood. 105: 2955-62. Nakatani, Y. et al., 2005, Mediators Inflamm. 2005: 280-292. Bjoerk, P. et al., 2009, PLoS Biol. 7: E97-E97.