Human PRTFDC1 Protein (His Tag)
HHGP,PRTFDC1
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| Catalog Number | P14023-H07E |
|---|---|
| Organism Species | Human |
| Host | E. coli |
| Synonyms | HHGP,PRTFDC1 |
| Molecular Weight | The recombinant human PRTFDC1 consists of 240 amino acids and predicts a molecular mass of 27.5 KDa. It migrates as an approximately 19 KDa band in SDS-PAGE under reducing conditions. |
| predicted N | His |
| SDS-PAGE |  |
| Purity | > 95 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the mature form of human PRTFDC1 (Q9NRG1-1) (Met1-Val225) was expressed with a polyhistide tag at the N-terminus. |
| Bio-activity | |
| Research Area | Epigenetics |DNA / RNA |Translation |Ribosome |
| Formulation | Lyophilized from sterile 50mM Tris, 10% glycerol, pH 8.0 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | PRTFDC1 is a member of the purine/pyrimidine phosphoribosyltransferase family. It can bind GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP). The epigenetic silencing of PRTFDC1 by hypermethylation of the CpG island leads to a loss of PRTFDC1 function, which might be involved in squamous cell oral carcinogenesis. PRTFDC1 is a genetic modifier of HPRT-deficiency in the mouse and has important implications for unraveling the molecular etiology of lesch-Nyhan disease(LND). LND is a severe X-linked neurological disorder caused by a deficiency of hypoxanthine phosphoribosyltransferase. PRTFDC1 has a low, barely measurable phosphoribosyltransferase activity (in vitro). |
| Reference |