Human LSM3 Protein (His Tag)

SMX4,USS2,YLR438C

Catalog Number	P14554-H07E
Organism Species	Human
Host	E. coli
Synonyms	SMX4,USS2,YLR438C
Molecular Weight	The recombinant human LSM3 consists of 117 amino acids and predicts a molecular mass of 13.7 KDa. It migrates as an approximately 14-18 KDa band in SDS-PAGE under reducing conditions.
predicted N	His
SDS-PAGE
Purity	> 95 % as determined by SDS-PAGE
Protein Construction	A DNA sequence encoding the mature form of human LSM3 (Met1-Gly102) was expressed with a polyhistide tag at the N-terminus.
Bio-activity
Research Area	Epigenetics \|DNA / RNA \|RNA Processing \|Other in RNA processing
Formulation	Lyophilized from sterile PBS, 10% glycerol, pH 7.4 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background	LSM3 is a member of the snRNP Sm proteins family. Sm-like proteins can be detected in a variety of organisms. They all have the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing. LSM3binds specifically to the 3'-terminal U-tract of U6 snRNA.
Reference	Gerhard DS. et al., 2004, Genome Res. 14 (10B): 2121-7. Lehner B. et al., 2004, Genome Res. 14 (7): 1315-23. Lehner B. et al., 2004, Genomics. 83 (1): 153-67.