Human Cyclophilin A / PPIA / CYPA Protein (His Tag)

CYPA,CYPH,HEL-S-69p

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Catalog Number	P10436-H08E
Organism Species	Human
Host	E. coli
Synonyms	CYPA,CYPH,HEL-S-69p
Molecular Weight	The recombinant human PPIA consisting of 175 amino acids and has a calculated molecular mass of 19.4 kDa as estimated in SDS-PAGE under reducing conditions.
predicted N	Met 1
SDS-PAGE
Purity	> 97 % as determined by SDS-PAGE
Protein Construction	A DNA sequence encoding the human PPIA (P62937) (Met 1-Glu 165) was expressed, with a polyhistide tag at the C-terminus.
Bio-activity
Research Area	Microbiology |Pathogenic microorganism |viruses |animal virus |viral illness |Central nervous system diseases |
Formulation	Lyophilized from sterile 50mM Tris, 150mM NaCl, 20% glycerol, pH 7.7 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background	Mouse peptidyl-prolyl cis-trans isomerase A, also known as PPIase A, Rotamase A, Cyclophilin A, Cyclosporin A-binding protein, PPIA and CYPA, is a cytoplasm protein which belongs to the cyclophilin-type PPIase family and PPIase A subfamily. Cyclophilins (CyPs) are a family of proteins found in organisms ranging from prokaryotes to humans. These molecules exhibit peptidyl-prolyl isomerase activity, suggesting that they influence the conformation of proteins in cells. PPIA / Cyclophilin A accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. PPIA / Cyclophilin A is secreted by vascular smooth muscle cells in response to inflammatory stimuli, and could thus contribute to atherosclerosis. It is not essential for mammalian cell viability. PPIA / Cyclophilin A can interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions.
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