Human CIB2 / KIP-2 Protein (His Tag)

DFNB48,KIP2,USH1J

• 100ug (NPP2016) Please inquiry

Catalog Number	P12596-H07E
Organism Species	Human
Host	E. coli
Synonyms	DFNB48,KIP2,USH1J
Molecular Weight	The recombinant human CIB2 consisting of 198 amino acids and has a calculated molecular mass of 23.1 kDa. The apparent molecular mass of the protein is approximately 27 kDa in SDS-PAGE under reducing conditions.
predicted N	Met
SDS-PAGE
Purity	> 75 % as determined by SDS-PAGE
Protein Construction	A DNA sequence encoding the mature form of human CIB2 (O75838) (Met 1-Ile 187) was expressed, with a polyhistide tag at the N-terminus.
Bio-activity
Research Area	Signaling |Signal Transduction |Signaling Pathway |Calcium Signaling |Calcium Binding Proteins
Formulation	Lyophilized from sterile 50mM Tris, 20% glycerol, pH 8.0 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background
Reference	Blazejczyk M, et al. (2006) Myristoylation and membranous localization of Calmyrin2, a new member of Neuronal Calcium-Sensor proteins. FENS Forum Abstracts. 3. Hollenbach AD, et al. (2006) The EF-hand calcium-binding protein calmyrin inhibits the transcriptional and DNA-binding activity of Pax3. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1574(3): 321-8. Blazejczyk M, et al. (2009) Biochemical characterization and expression analysis of a novel EF-hand Ca2+ binding protein calmyrin2 (Cib2) in brain indicates its function in NMDA receptor mediated Ca2+ signaling. Archives of Biochemistry and Biophysics. 487(1): 66-78.