Human CAPG / AFCP Protein

AFCP,HEL-S-66,MCP

Catalog Number	P14213-HNAE
Organism Species	Human
Host	E. coli
Synonyms	AFCP,HEL-S-66,MCP
Molecular Weight	The recombinant human CAPG consists of 348 amino acids and predicts a molecular mass of 38.5 KDa. It migrates as an approximately 43 KDa band in SDS-PAGE under reducing conditions.
predicted N	Met
SDS-PAGE
Purity	> 95 % as determined by SDS-PAGE
Protein Construction	A DNA sequence encoding human CAPG(AAH14549.1) (Met1-Lys348) was expressed.
Bio-activity
Research Area	Signaling \|Signal Transduction \|Cytoskeleton / ECM \|Cytoskeletal Proteins \|Microfilaments \|Actin etc \|
Formulation	Lyophilized from sterile 20mM tris, 10% glycerol, pH 8.0. 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background	CAPG, also known as actin Regulatory Protein CAPG, is a a member of the gelsolin/villin family. Members of this family are actin-regulatory proteins. CAPG reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, CAPG contributes to the control of actin-based motility in non-muscle cells. CAPG may also play an important role in macrophage function.
Reference	Watari A. et al., 2007, Oncogene. 25 (56): 7373-80. De Corte V. et al., 2005, J Cell Sci. 117 (22): 5283-92. Van Impe K. et al., 2003, J Biol Chem. 278 (20): 17945-52.