Human C6 / complement component 6 Protein (His Tag)

C6

Catalog Number	P12426-H08H
Organism Species	Human
Host	Human Cells
Synonyms	C6
Molecular Weight	The secreted recombinant human C6 comprises 924 amino acids and has a predicted molecular mass of 104 kDa. The apparent molecular mass of rh C6 is approximately 110 kDa in SDS-PAGE under reducing conditions.
predicted N	Cys 22
SDS-PAGE
Purity	> 90 % as determined by SDS-PAGE
Protein Construction	A DNA sequence encoding the human C6 (AAA59668.1) (Met 1-Ala 934) was fused with a polyhistidine tag at the C-terminus.
Bio-activity
Research Area	Immunology \|Innate Immunity \|Complement System \|MAC
Formulation	Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background
Reference	Lengweiler S, et al. (1997) Elucidation of the disulfide-bonding pattern in the factor I modules of the sixth component (C6) of human complement. Biochim Biophys Acta. 1342 (1): 13-8. Chakravarti DN, et al. (1989) Structural homology of complement protein C6 with other channel-forming proteins of complement. Proc Natl Acad Sci U S A. 86 (8): 2799-803. DiScipio RG, et al. (1989) The molecular architecture of human complement component C6. J Biol Chem. 264 (27): 16197-206.