Human BMF / Bcl2 modifying factor Protein (His Tag)
BMF
- 100ug (NPP1931) Please inquiry
| Catalog Number | P13639-H07E |
|---|---|
| Organism Species | Human |
| Host | E. coli |
| Synonyms | BMF |
| Molecular Weight | The recombinant human BMF consists of 199 amino acids and predicts a molecular mass of 22.3 KDa. It migrates as an approximately 25 KDa band in SDS-PAGE under reducing conditions. |
| predicted N | His |
| SDS-PAGE |  |
| Purity | > 85 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the mature form of human BMF (Q96LC9-1) (Met1-Arg184) was expressed with a polyhistide tag at the N-terminus. |
| Bio-activity | |
| Research Area | Cancer |Signal transduction |Cytoskeleton / ECM |Cytoskeletal Proteins |Motor Proteins |Dynein | |
| Formulation | Lyophilized from sterile 50mM Tris, 0.1% Brij35, pH 8.0. 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | BMF(Bcl2 modifying factor) belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BMF contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. BMF is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified. |
| Reference |