Human BCL6 / B-cell CLL lymphoma 6 Protein (aa 1-150, His & Trx Tag)
BCL5,BCL6A,LAZ3,ZBTB27,ZNF51
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| Catalog Number | P12083-H30E |
|---|---|
| Organism Species | Human |
| Host | E. coli |
| Synonyms | BCL5,BCL6A,LAZ3,ZBTB27,ZNF51 |
| Molecular Weight | The recombinant human BCL6/Trx fusion protein consisting of 309 amino acids and has a calculated molecular mass of 34.2 kDa. It migrates as an approximately 33 kDa band in SDS-PAGE under reducing conditions. |
| predicted N | Met |
| SDS-PAGE |  |
| Purity | > 92 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the human BCL6 (P41182) N-terminal fragment (Met 1-Met 150) was fused with a Trx and a polyhistidine tag at the N-terminus. |
| Bio-activity | |
| Research Area | Epigenetics |Transcription |Transcription Factor & Regulator |Transcriptional Co-Repressors |
| Formulation | Lyophilized from sterile 20mM Tris, 10% glycerol, pH 8.0 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | The protein encoded by this gene is an evolutionarily conserved 95-kDa protein containing six C-terminal zinc-finger motifs and an N-terminal POZ domain. It has been reported that BCL-6 is present in DNA-binding complexes in nuclear extracts from various B-cell lines. There are many relationships between non-Hodgkin's lymphoma, diffuse large cell lymphoma and BCL6’s translocations. BCL6 can repress transcription from promoters linked to its DNA target sequence and this activity is dependent upon specific DNA-binding and the presence of an intact N-terminal half of the protein. |
| Reference |