Human Angiopoietin 4 / ANG4 / ANGPT4 Protein (His Tag)

AGP4,ANG-3,ANG4

Catalog Number	P10293-H07H
Organism Species	Human
Host	Human Cells
Synonyms	AGP4,ANG-3,ANG4
Molecular Weight	The recombinant human ANGPT4 comprises 242 amino acids and has a predicted molecular mass of 27.6 kDa. The apparent molecular mass of the protein is approximately 38 kDa in SDS-PAGE under reducing conditions due to glycosylation.
predicted N	His
SDS-PAGE
Purity	> 80 % as determined by SDS-PAGE
Protein Construction	A DNA sequence encoding the human ANGPT4 (NP_068769.2) (Met282-Ile503) was expressed, with an N-terminal polyhistidine tag.
Bio-activity
Research Area	Cancer \|Signal transduction \|Metabolism \|Pathways and Processes \|Metabolism processes \|Apoptosis \|
Formulation	Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background
Reference	Grosios K, et al. (1999) Assignment of ANGPT4, ANGPT1, and ANGPT2 encoding angiopoietins 4, 1 and 2 to human chromosome bands 20p13, 8q22.3?q23 and 8p23.1, respectively, by in situ hybridization and radiation hybrid mapping. Cytogenet. Cell Genet. 84 (1-2): 118-20. Yamakawa M, et al. (2004) Expression of angiopoietins in renal epithelial and clear cell carcinoma cells: regulation by hypoxia and participation in angiogenesis. Am J Physiol Renal Physiol. 287 (4): 649-57. Oliner J, et al. (2004) Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2. Cancer Cell. 6 (5): 507-16.