Human AK1 / Adenylate kinase 1 Protein (His Tag)

HTL-S-58j

Catalog Number	P12442-H07E
Organism Species	Human
Host	E. coli
Synonyms	HTL-S-58j
Molecular Weight	The recombinant human AK1 consisting of 209 amino acids and has a calculated molecular mass of 23.5 kDa. It migrates as an approximately 25 kDa band in SDS-PAGE under reducing conditions.
predicted N	Met
SDS-PAGE
Purity	> 90 % as determined by SDS-PAGE
Protein Construction	A DNA sequence encoding the human AK1 (AAH01116.1) (Met 1-Lys 194) was expressed, with a polyhistide tag at the N-terminus.
Bio-activity	Kinase activity untested
Research Area
Formulation	Supplied as sterile PBS, 10% glycerol, pH 7.5 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background
Reference	Lu Q, et al. (1996) Adenylate kinase complements nucleoside diphosphate kinase deficiency in nucleotide metabolism. Proc Natl Acad Sci. 93 (12): 5720-5. Dzeja P, et al. (2009) Adenylate kinase and AMP signaling networks: Metabolic monitoring, signal communication and body energy sensing. Int J Mol Sci. 10 (4): 1729-72. Lagresle-Peyrou C, et al. (2008) Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness. Nature Genetics. 41: 106 - 11.