Cynomolgus IL13 / ALRH Protein
IL13
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| Catalog Number | P11057-CNAH |
|---|---|
| Organism Species | Cynomolgus |
| Host | Human Cells |
| Synonyms | IL13 |
| Molecular Weight | The recombinant Cynomolgus IL13 consists of 112 amino acids and has a calculated molecular mass of 12.3 kDa as estimated by SDS-PAGE under reducing conditions. |
| predicted N | Ser 21 |
| SDS-PAGE |  |
| Purity | > 85 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the Cynomolgus (Macaca fascicularis) IL13 (ABG75889.1) (Met 1-Asn 132) precursor was expressed. |
| Bio-activity | Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is typically 2-8 ng/mL. |
| Research Area | Immunology |Inflammation / Inflammatory Mediator |Inflammatory Disorders Therapeutic Targets |Asthma Therapeutic Targets |
| Formulation | Lyophilized from sterile PBS, pH 7.4. 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | Interleukin 13 (IL-13) is a single-chain glycosylated polypeptide, which belongs to the IL-13/IL-4 family. IL-13 protein is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL-13 exerts its effects through a multi-subunit receptor comprising the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains (IL-13 Rα1 and IL-13 Rα2). As a cytokine, IL-13 protein is critical in regulating inflammatory, immune responses and diseases. In addition, it inhibits the production of pro-inflammatory cytokines and chemokines, and thus down-regulates macrophage activity. IL-13 protein and antibody is more importantly implicated as a central mediator of immunoregulatory processes in various cell types. |
| Reference |